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The company

Madrigal Pharmaceuticals, Inc.

MDGL · Nasdaq

Health CarePharmaceuticalsNot moving yet

MDGL stood above a rising 150-day average in 31 of the last 52 weekly readings, and has been out of that trend for the last 3 weeks. It is 12.8% below that average now. Pharmaceuticals: 32% of its 74 stocks in an uptrend (−7 points in four weeks); Health Care: 26% (−10 points in four weeks).

Statistics

Rotation
Not moving yet
Weeks in an uptrend
out for 3
Industry in uptrend
32% -7 in 4 wk
Insider buys, 12 months
$0
Insider sales, 12 months
$121.6M
Officials’ trades on record
1
Institutions holding
385 (+33)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 31 of 52 weeks.

20 Apr – 19 Oct
26%34%43%Apr 26Jun 26Jul 26Sep 26Oct 26

Pharmaceuticals: A minority of its stocks are in an uptrend and the share has been slipping. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026
−$82.7M$0$56.5MNov 24May 25Nov 25Apr 26Oct 26

Open-market buys above the line and sales below, in dollars.

Congress and officials

1 disclosed lines: House 1, Senate 0, executive 0; 1 people.

WhoDidAmountTraded
Daniel S. Goldman House: U.S. House ClerkNY10sold$1k–$15k10 Apr 2023filed 19 May 2023

Insiders

Buy orders, 12 months0
Sale orders, 12 months29
Buyers · sellers0 · 9
WhoDidSharesTraded
William John SiboldPresident and CEOsold60at $533.0911 Sep 2026filed 11 Sep 2026
William John SiboldPresident and CEOsold106at $534.0611 Sep 2026filed 11 Sep 2026
William John SiboldPresident and CEOsold218at $535.9411 Sep 2026filed 11 Sep 2026
William John SiboldPresident and CEOsold160at $537.6211 Sep 2026filed 11 Sep 2026
William John SiboldPresident and CEOsold687at $540.5911 Sep 2026filed 11 Sep 2026
William John SiboldPresident and CEOsold368at $541.6411 Sep 2026filed 11 Sep 2026
William John SiboldPresident and CEOsold1,202at $542.6011 Sep 2026filed 11 Sep 2026
William John SiboldPresident and CEOsold1,539at $544.0211 Sep 2026filed 11 Sep 2026
William John SiboldPresident and CEOsold761at $544.8311 Sep 2026filed 11 Sep 2026
William John SiboldPresident and CEOsold120at $546.3811 Sep 2026filed 11 Sep 2026
William John SiboldPresident and CEOsold131at $527.889 Sep 2026filed 11 Sep 2026
William John SiboldPresident and CEOsold347at $529.279 Sep 2026filed 11 Sep 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders385+33 on the quarter
New · exited77 · 44
Reported value$12.4B

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

ManagerSharesChange
BAKER BROS. ADVISORS LPadded · filed 14 Aug 20262,143,131$1.2B+1,430+0.1%
RTW INVESTMENTS, LPunchanged · filed 14 Aug 20261,993,687$1.1B00.0%
Jupiter Topco LLCnew · filed 14 Aug 20261,936,099$1.0B+1,936,099
Avoro Capital Advisors LLCadded · filed 14 Aug 20261,833,333$984.4M+15,152+0.8%
PAULSON & CO. INC.reduced · filed 14 Aug 20261,340,020$719.5M-52,168−3.7%
BlackRock, Inc.reduced · filed 7 Aug 20261,200,770$644.8M-359,195−23.0%
VANGUARD CAPITAL MANAGEMENT LLCadded · filed 13 Aug 2026835,668$448.7M+8,524+1.0%
WELLINGTON MANAGEMENT GROUP LLPadded · filed 14 Aug 2026825,714$443.4M+130,756+18.8%
VANGUARD PORTFOLIO MANAGEMENT LLCreduced · filed 13 Aug 2026781,731$419.8M-59,414−7.1%
STATE STREET CORPreduced · filed 7 Aug 2026527,057$283.0M-82,468−13.5%
31 Mar 2023 – 30 Jun 2026
182280377Mar 23Dec 23Dec 24Sep 25Jun 26

Everyone who traded it

William John Sibold Company insiderPresident and CEO · last 11 Sep 20260 · 10
Shannon T. Kelley Company insiderGeneral Counsel · last 17 Aug 20260 · 6
John C. Reed Company insiderDirector · last 15 Aug 20260 · 0
BAKER BROS. ADVISORS LP Company insiderDirector · last 17 Jun 20262 · 0
Baker Brothers Life Sciences Lp Company insiderDirector · last 17 Jun 20262 · 0
Daniel J. Brennan Company insiderDirector · last 17 Jun 20260 · 0
Jacqualyn A. Fouse Company insiderDirector · last 17 Jun 20260 · 0
James M. Daly Company insiderDirector · last 17 Jun 20260 · 3
Rebecca Taub Company insiderDirector · last 17 Jun 20260 · 18
Richard S. Levy Company insiderDirector · last 17 Jun 20263 · 6
David Soergel Company insiderChief Medical Officer · last 1 Jun 20260 · 2
Carole Huntsman Company insiderChief Commercial Officer · last 6 Mar 20260 · 6

Same industry

ABBV AbbVieLeading+19%

Distance from each stock’s own 150-day average.

Government contracts

No federal award is tied to it.

From its SEC filings

Operating profit marginFY 2025 · to 31 Dec 2025-31.3%
Free cash flow marginFY 2025 · to 31 Dec 2025-19.8%
Return on capital employedFY 2025 · to 31 Dec 2025-31.6%
Debt to equityFY 2025 · to 31 Dec 20250.56×
Share count trendFY 2025 · to 12 Feb 20260.4%
Cash and equivalentsFY 2025 · to 31 Dec 2025$198.7M
Free cash flowFY 2025 · to 31 Dec 2025−$190.0M

Analyst forecasts

No analyst forecasts yet.