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The company

Orchestra BioMed Holdings, Inc. -

OBIO · Nasdaq

Health CareMedical DevicesLeading

OBIO stood above a rising 150-day average in 32 of the last 52 weekly readings, including each of the last 9 weeks. It is 19.5% above that average now. Medical Devices: 27% of its 181 stocks in an uptrend (−9 points in four weeks); Health Care: 25% (−11 points in four weeks).

SEC filings

Statistics

Rotation: Leading
Weeks in an uptrend: 9 in a row
Industry in uptrend: 27% -9 in 4 wk
Insider buys, 12 months: $539K
Insider sales, 12 months: $611K
Officials’ trades on record: 0
Institutions holding: 76 (+13)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 32 of 52 weeks.

17 Apr – 16 Oct

Medical Devices: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months9

Sale orders, 12 months6

Buyers · sellers4 · 2

Who	Did	Shares	Traded
Darren ShermanDirector, Officer	sold	15,000at $6.36	1 Oct 2026filed 2 Oct 2026
David P. HochmanDirector, Officer	bought	10,000at $4.79	3 Sep 2026filed 8 Sep 2026
Darren ShermanDirector, Officer	sold	15,000at $4.94	1 Sep 2026filed 2 Sep 2026
Darren ShermanDirector, Officer	bought	2,000at $5.33	26 Aug 2026filed 28 Aug 2026
Darren ShermanDirector, Officer	sold	15,000at $4.09	3 Aug 2026filed 4 Aug 2026
Darren ShermanDirector, Officer	sold	15,000at $4.27	1 Jul 2026filed 2 Jul 2026
Darren ShermanDirector, Officer	sold	15,000at $3.87	1 Jun 2026filed 2 Jun 2026
David P. HochmanDirector, Officer	bought	5,000at $3.83	1 Jun 2026filed 2 Jun 2026
Jason AryehDirector	bought	665at $3.75	18 May 2026filed 20 May 2026
David P. HochmanDirector, Officer	bought	5,000at $3.77	15 May 2026filed 19 May 2026
Jason AryehDirector	bought	8,971at $3.90	15 May 2026filed 19 May 2026
Eric S. FainDirector	bought	20,000at $4.13	14 May 2026filed 18 May 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders76+13 on the quarter

New · exited25 · 13

Reported value$120.8M

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
RTW INVESTMENTS, LPadded · filed 14 Aug 2026	9,556,063$41.2M	+1,250,000+15.0%
PERCEPTIVE ADVISORS LLCunchanged · filed 14 Aug 2026	5,037,906$21.7M	00.0%
BlackRock, Inc.added · filed 7 Aug 2026	2,510,387$10.8M	+1,874,673+294.9%
VANGUARD CAPITAL MANAGEMENT LLCreduced · filed 13 Aug 2026	2,022,916$8.7M	-181,403−8.2%
GEODE CAPITAL MANAGEMENT, LLCadded · filed 12 Aug 2026	1,007,908$4.4M	+522,416+107.6%
Alyeska Investment Group, L.P.unchanged · filed 14 Aug 2026	1,000,000$4.3M	00.0%
Propel Bio Management, LLCunchanged · filed 13 Aug 2026	896,701$3.9M	00.0%
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLCnew · filed 13 Aug 2026	642,154$2.8M	+642,154
STATE STREET CORPadded · filed 7 Aug 2026	516,050$2.2M	+346,640+204.6%
RICE HALL JAMES & ASSOCIATES, LLCadded · filed 7 Aug 2026	424,000$1.8M	+404,999+2131.5%