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Who

Opaleye Management Inc.

10% owner

Company insider

Files Form 4 as: 10% owner, Grace Therapeutics; 10% owner, Alpha Cognition; 10% owner, Sol-Gel Technologies; 10% owner, Eton Pharmaceuticals; 10% owner, SANUWAVE Health; 10% owner, Harrow; 10% owner, Codexis; 10% owner, Protara Therapeutics.

Every Form 4 they filed

In numbers

Trades disclosed
675
Buys
298
Sells
80
Bought
$85.6M
Sold
$61.2M
Companies
11
Companies where not an officer
11
First trade
19 May 2015
Last trade
19 Oct 2026
Last filed
21 Oct 2026

Companies traded

Everywhere else they filed: board seats, 10% stakes, other companies
GRCE Grace Therapeutics10% owner · Biotechnology · last 19 Oct 202618 buys · 0 sells
ACOG Alpha Cognition10% owner · Biotechnology · last 16 Oct 202649 buys · 0 sells
SLGL Sol-Gel Technologies10% owner · Pharmaceuticals · last 11 Sep 202643 buys · 0 sells
ETON Eton Pharmaceuticals10% owner · Pharmaceuticals · last 14 Jul 20268 buys · 23 sells
SNWV SANUWAVE Health10% owner · Medical Devices · last 1 May 20265 buys · 6 sells
HROW Harrow10% owner · Pharmaceuticals · last 4 Mar 202643 buys · 16 sells
CDXS Codexis10% owner · Chemicals · last 1 Dec 202542 buys · 13 sells
TARA Protara Therapeutics10% owner · Biotechnology · last 12 Sep 202419 buys · 20 sells
Tracon Pharmaceuticals10% owner · last 10 Nov 202348 buys · 2 sells
TELA TELA Bio10% owner · Medical Devices · last 3 Nov 202221 buys · 0 sells
OCUL Ocular Therapeutix10% owner · Biotechnology · last 2 Jan 20202 buys · 0 sells

Activity over time

1 Nov 2024 – 1 Oct 2026
10018Nov 24May 25Nov 25Apr 26Oct 26

Buys above the line, sells below, each month.

Every trade

TradedCompanyWhatAmount
19 Oct 2026filed 21 Oct 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$8,0014,256 at $1.88filing
16 Oct 2026filed 19 Oct 2026ACOG Alpha CognitionBiotechnologySEC FORM 4 Bought$118K14,283 at $8.23filing
16 Oct 2026filed 16 Oct 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$69K36,347 at $1.89filing
15 Oct 2026filed 19 Oct 2026ACOG Alpha CognitionBiotechnologySEC FORM 4 Bought$191K22,657 at $8.43filing
15 Oct 2026filed 16 Oct 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$46K23,485 at $1.95filing
14 Oct 2026filed 16 Oct 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$22K11,233 at $1.93filing
12 Oct 2026filed 13 Oct 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$15K7,215 at $2.02filing
9 Oct 2026filed 13 Oct 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$11K5,340 at $2.04filing
8 Oct 2026filed 13 Oct 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$4,1902,077 at $2.02filing
5 Oct 2026filed 5 Oct 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$3,4901,694 at $2.06filing
2 Oct 2026filed 5 Oct 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$41K20,000 at $2.07filing
1 Oct 2026filed 5 Oct 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$79K38,796 at $2.04filing
1 Oct 2026filed 2 Oct 2026ACOG Alpha CognitionBiotechnologySEC FORM 4 Bought$166K19,050 at $8.69filing
29 Sep 2026filed 1 Oct 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$16K7,849 at $2.09filing
25 Sep 2026filed 28 Sep 2026ACOG Alpha CognitionBiotechnologySEC FORM 4 Bought$114K13,426 at $8.47filing
25 Sep 2026filed 28 Sep 2026ACOG Alpha CognitionBiotechnologySEC FORM 4 Bought$114K13,426 at $8.47filing
24 Sep 2026filed 28 Sep 2026ACOG Alpha CognitionBiotechnologySEC FORM 4 Bought$157K18,337 at $8.57filing
24 Sep 2026filed 28 Sep 2026ACOG Alpha CognitionBiotechnologySEC FORM 4 Bought$157K18,337 at $8.57filing
23 Sep 2026filed 1 Oct 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$11K5,318 at $2.10filing
23 Sep 2026filed 23 Sep 2026GRCE Grace TherapeuticsBiotechnologySEC FORM 4 Bought$11K5,318 at $2.10filing

The newest 500 lines are listed; the numbers count every line.

News

Opaleye Management Inc. Acquires 1,631 Shares of Sol-Gel Technologies (NASDAQ:SLGL) Stockthemarketsdaily.com · 15 Sep 2026Contrasting Eton Pharmaceuticals (NASDAQ:ETON) and Biofrontera (NASDAQ:BFRI)ETON · themarketsdaily.com · 24 Oct 2026Codexis (NASDAQ:CDXS) and Revvity (NYSE:RVTY) Head-To-Head ComparisonCDXS · themarketsdaily.com · 19 Oct 2026Grace Therapeutics (NASDAQ:GRCE) Upgraded at Wall Street ZenGRCE · themarketsdaily.com · 15 Oct 2026Eton (NASDAQ: ETON) secures LIBERVANT license with milestones up to $47.5 millionETON · themarketsdaily.com · 14 Oct 2026Eton Pharmaceuticals and Aquestive Therapeutics Announce Exclusive U.S. Licensing Agreement for LIBERVANT® (diazepam) Buccal FilmETON · manilatimes.net · 14 Oct 2026Alpha Cognition Announces Publication of U.S. Patent Application Relating to Proprietary Manufacturing Process for ZUNVEYL®ACOG · standard-freeholder.com · 13 Oct 2026Alpha Cognition Inc. (NASDAQ:ACOG) Stock Now Rated "Buy" by Sell-Side BrokeragesACOG · dailypolitical.com · 13 Oct 2026

1 headline in the last 90 days name Opaleye Management Inc.; 8 articles from the last 14 days about the 6 companies they traded most, at most three about any one of them.

Sectors

Health Care273
Materials55
Not placed50

Buys in green, sells in red, by the company’s sector.

Related people

David KrempaChief Business Officer · Chief Business Officer at Eton Pharmaceuticals, filing Form 4 there in the last year
Ian D. MillerDirector · Director at SANUWAVE Health, filing Form 4 there in the last year
Morgan C. FrankChief Executive Officer · Chief Executive Officer at SANUWAVE Health, filing Form 4 there in the last year
James TylerDirector · Director at SANUWAVE Health, filing Form 4 there in the last year
Gregory Matthew BazarDirector · Director at SANUWAVE Health, filing Form 4 there in the last year
Alison MoorePresident and CEO · Also traded CDXS in the last 90 days
Georgia ErbezOfficer · Also traded CDXS in the last 90 days
Todd AndermanChief Legal Officer · Also traded OCUL in the last 90 days