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The company

Annovis Bio, Inc.

ANVS · NYSE

Health CareBiotechnologyNot moving yet

ANVS stood above a rising 150-day average in 11 of the last 52 weekly readings, and has been out of that trend for the last 38 weeks. It is 44.4% below that average now. Biotechnology: 15% of its 561 stocks in an uptrend (−17 points in four weeks); Health Care: 25% (−11 points in four weeks).

SEC filings

Statistics

Rotation: Not moving yet
Weeks in an uptrend: out for 38
Industry in uptrend: 15% -17 in 4 wk
Insider buys, 12 months: $6.1M
Insider sales, 12 months: $0
Officials’ trades on record: 0
Institutions holding: 58 (+9)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 11 of 52 weeks.

17 Apr – 16 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months9

Sale orders, 12 months0

Buyers · sellers2 · 0

Who	Did	Shares	Traded
Michael B. HoffmanDirector	bought	2,562at $1.75	20 May 2026filed 21 May 2026
Michael B. HoffmanDirector	bought	18,849at $1.80	20 May 2026filed 21 May 2026
Michael B. HoffmanDirector	bought	54,933at $1.90	20 May 2026filed 21 May 2026
Michael B. HoffmanDirector	bought	713,800at $2.10	2 Apr 2026filed 3 Apr 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders58+9 on the quarter

New · exited17 · 8

Reported value$20.0M

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
Empery Asset Management, LPnew · filed 11 Aug 2026	2,401,476$4.5M	+2,401,476
MARSHALL WACE, LLPadded · filed 13 Aug 2026	1,842,339$3.4M	+654,840+55.1%
VANGUARD CAPITAL MANAGEMENT LLCadded · filed 13 Aug 2026	1,647,322$3.1M	+774,941+88.8%
TUDOR INVESTMENT CORP ET ALnew · filed 14 Aug 2026	1,357,134$2.5M	+1,357,134
RENAISSANCE TECHNOLOGIES LLCadded · filed 13 Aug 2026	1,002,200$1.9M	+654,600+188.3%
TWO SIGMA INVESTMENTS, LPreduced · filed 14 Aug 2026	579,571$1.1M	-48,088−7.7%
GEODE CAPITAL MANAGEMENT, LLCadded · filed 12 Aug 2026	283,817$528K	+36,304+14.7%
BlackRock, Inc.added · filed 7 Aug 2026	249,856$465K	+110,323+79.1%
CITADEL ADVISORS LLCnew · filed 14 Aug 2026	243,682$453K	+243,682
VANGUARD FIDUCIARY TRUST COadded · filed 13 Aug 2026	177,530$330K	+45,488+34.4%