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The company

Denali Therapeutics Inc.

DNLI · Nasdaq

Health CareBiotechnologyNot moving yet

DNLI stood above a rising 150-day average in 43 of the last 52 weekly readings, and has been out of that trend for the last 6 weeks. It is 16.4% below that average now. Biotechnology: 16% of its 561 stocks in an uptrend (−15 points in four weeks); Health Care: 26% (−10 points in four weeks).

SEC filings

Statistics

Rotation: Not moving yet
Weeks in an uptrend: out for 6
Industry in uptrend: 16% -15 in 4 wk
Insider buys, 12 months: $0
Insider sales, 12 months: $2.6M
Officials’ trades on record: 0
Institutions holding: 274 (+22)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 43 of 52 weeks.

20 Apr – 19 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months0

Sale orders, 12 months6

Buyers · sellers0 · 4

Who	Did	Shares	Traded
Peter Scott ChinChief Medical Officer	sold	1,654at $22.29	4 Sep 2026filed 9 Sep 2026
Nancy ThornberryDirector	sold	10,824at $22.85	2 Sep 2026filed 4 Sep 2026
Nancy ThornberryDirector	sold	615at $23.74	2 Sep 2026filed 4 Sep 2026
Alexander O. SchuthCOFO and Secretary	sold	2,768at $23.44	1 Sep 2026filed 3 Sep 2026
Alexander O. SchuthCOFO and Secretary	sold	2,857at $25.07	11 Aug 2026filed 13 Aug 2026
Ryan J. WattsPresident and CEO	sold	35,198at $16.50	6 Jan 2026filed 8 Jan 2026
Alexander O. SchuthCOFO and Secretary	sold	17,218at $16.50	6 Jan 2026filed 8 Jan 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders274+22 on the quarter

New · exited53 · 30

Reported value$3.5B

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
BlackRock, Inc.added · filed 7 Aug 2026	14,026,413$360.8M	+991,979+7.6%
BAILLIE GIFFORD & COreduced · filed 6 Aug 2026	11,960,230$307.6M	-106,249−0.9%
STATE STREET CORPadded · filed 7 Aug 2026	7,049,304$181.3M	+777,303+12.4%
Temasek Holdings (Private) Ltdunchanged · filed 7 Aug 2026	7,012,974$180.4M	00.0%
VANGUARD PORTFOLIO MANAGEMENT LLCadded · filed 13 Aug 2026	6,477,057$166.6M	+356,897+5.8%
VANGUARD CAPITAL MANAGEMENT LLCadded · filed 13 Aug 2026	6,275,729$161.4M	+127,772+2.1%
FMR LLCreduced · filed 13 Aug 2026	4,535,836$116.7M	-39,538−0.9%
GOLDMAN SACHS GROUP INCreduced · filed 14 Aug 2026	4,155,895$106.9M	-251,360−5.7%
GEODE CAPITAL MANAGEMENT, LLCadded · filed 12 Aug 2026	3,973,342$102.2M	+246,228+6.6%
Holocene Advisors, LPadded · filed 14 Aug 2026	3,905,225$100.4M	+709,796+22.2%