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The company

Design Therapeutics, Inc.

DSGN · Nasdaq

Health CareBiotechnologyNot moving yetSynthetic Biology / TechBio

DSGN stood above a rising 150-day average in 47 of the last 52 weekly readings, and has been out of that trend for the last 5 weeks. It is 19.4% below that average now. Biotechnology: 15% of its 561 stocks in an uptrend (−17 points in four weeks); Health Care: 25% (−11 points in four weeks).

SEC filings

Statistics

Rotation: Not moving yet
Weeks in an uptrend: out for 5
Industry in uptrend: 15% -17 in 4 wk
Insider buys, 12 months: $0
Insider sales, 12 months: $0
Officials’ trades on record: 0
Institutions holding: 134 (+14)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 47 of 52 weeks.

17 Apr – 16 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months0

Sale orders, 12 months0

Buyers · sellers0 · 0

No open-market buy or sale by its insiders on record.

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders134+14 on the quarter

New · exited31 · 17

Reported value$622.1M

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
SR One Capital Management, LPunchanged · filed 12 Aug 2026	6,526,476$94.4M	00.0%
Logos Global Management LPadded · filed 14 Aug 2026	3,000,000$43.4M	+1,050,000+53.8%
BAKER BROS. ADVISORS LPadded · filed 14 Aug 2026	2,678,430$38.8M	+92,452+3.6%
Driehaus Capital Management LLCadded · filed 14 Aug 2026	2,661,115$38.5M	+916,128+52.5%
BlackRock, Inc.added · filed 7 Aug 2026	2,660,024$38.5M	+526,260+24.7%
Point72 Asset Management, L.P.reduced · filed 14 Aug 2026	2,366,453$34.2M	-356,301−13.1%
Trails Edge Capital Partners, LPadded · filed 14 Aug 2026	2,001,282$29.0M	+1,149,269+134.9%
Frazier Life Sciences Management, L.P.new · filed 14 Aug 2026	1,809,854$26.2M	+1,809,854
Vivo Capital, LLCunchanged · filed 14 Aug 2026	1,612,903$23.3M	00.0%
VANGUARD CAPITAL MANAGEMENT LLCadded · filed 13 Aug 2026	1,571,022$22.7M	+221,172+16.4%