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The company

Karyopharm Therapeutics Inc.

KPTI · Nasdaq

Health CareBiotechnologyNot moving yet

KPTI stood above a rising 150-day average in 32 of the last 52 weekly readings, and has been out of that trend for the last 14 weeks. It is 94.1% below that average now. Biotechnology: 16% of its 561 stocks in an uptrend (−15 points in four weeks); Health Care: 26% (−10 points in four weeks).

SEC filings

Statistics

Rotation: Not moving yet
Weeks in an uptrend: out for 14
Industry in uptrend: 16% -15 in 4 wk
Insider buys, 12 months: $0
Insider sales, 12 months: $701K
Officials’ trades on record: 0
Institutions holding: 93 (+21)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 32 of 52 weeks.

20 Apr – 19 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months0

Sale orders, 12 months21

Buyers · sellers0 · 7

Who	Did	Shares	Traded
Kristin AbateChief Accounting Officer	sold	4,788at $0.344	16 Oct 2026filed 19 Oct 2026
Kristin AbateChief Accounting Officer	sold	378at $1.19	1 Oct 2026filed 2 Oct 2026
Kristin AbateChief Accounting Officer	sold	19at $2.02	1 Sep 2026filed 2 Sep 2026
Stuart PoultonEVP, Chief Development Officer	sold	189at $7.10	28 Jul 2026filed 30 Jul 2026
Michael ManoEVP, CLO&Secretary	sold	266at $9.50	14 May 2026filed 15 May 2026
Richard A. PaulsonPresident and CEO	sold	2,203at $9.50	14 May 2026filed 15 May 2026
Kristin AbateChief Accounting Officer	sold	53at $9.50	14 May 2026filed 15 May 2026
Sohanya Roshan ChengEVP & Chief Commercial Officer	sold	324at $9.50	14 May 2026filed 15 May 2026
Reshma RangwalaEVP & Chief Medical Officer	sold	408at $9.50	14 May 2026filed 15 May 2026
Stuart PoultonEVP, Chief Development Officer	sold	403at $9.50	14 May 2026filed 15 May 2026
Reshma RangwalaEVP & Chief Medical Officer	sold	449at $8.94	21 Apr 2026filed 22 Apr 2026
Richard A. PaulsonPresident and CEO	sold	12,361at $9.41	2 Mar 2026filed 3 Mar 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders93+21 on the quarter

New · exited35 · 14

Reported value$195.4M

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
RA CAPITAL MANAGEMENT, L.P.unchanged · filed 14 Aug 2026	1,917,354$18.7M	00.0%
ADAGE CAPITAL PARTNERS GP, L.L.C.reduced · filed 14 Aug 2026	1,521,322$14.9M	-285,000−15.8%
ACORN CAPITAL ADVISORS, LLCadded · filed 14 Aug 2026	1,518,113$14.8M	+1,230,287+427.4%
GOLDMAN SACHS GROUP INCadded · filed 14 Aug 2026	1,424,658$13.9M	+477,079+50.3%
BlackRock, Inc.added · filed 7 Aug 2026	1,418,799$13.9M	+1,173,900+479.3%
VANGUARD CAPITAL MANAGEMENT LLCadded · filed 13 Aug 2026	958,979$9.4M	+219,234+29.6%
Catalio Capital Management, LPadded · filed 14 Aug 2026	940,855$9.2M	+43,146+4.8%
Avidity Partners Management LPadded · filed 14 Aug 2026	924,487$9.0M	+460,746+99.4%
TWO SIGMA INVESTMENTS, LPadded · filed 14 Aug 2026	695,264$6.8M	+544,032+359.7%
Kalehua Capital Management LLCnew · filed 14 Aug 2026	685,644$6.7M	+685,644