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The company

Krystal Biotech, Inc.

KRYS · Nasdaq

Health CareBiotechnologyJust dropped out

KRYS stood above a rising 150-day average in 51 of the last 52 weekly readings, and has been out of that trend for the last 1 week. It is 0.3% below that average now. Biotechnology: 15% of its 561 stocks in an uptrend (−17 points in four weeks); Health Care: 25% (−11 points in four weeks).

Statistics

Rotation
Just dropped out
Weeks in an uptrend
out for 1
Industry in uptrend
15% -17 in 4 wk
Insider buys, 12 months
$0
Insider sales, 12 months
$188.5M
Officials’ trades on record
4
Institutions holding
391 (+49)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 51 of 52 weeks.

17 Apr – 16 Oct
16%28%39%Apr 26Jun 26Jul 26Sep 26Oct 26

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026
−$53.5M$0Nov 24May 25Nov 25Apr 26Oct 26

Open-market buys above the line and sales below, in dollars.

Congress and officials

4 disclosed lines: House 1, Senate 0, executive 3; 2 people.

WhoDidAmountTraded
Donald J. Trump Executive branch: Office of Government EthicsWhite House Officesold$100k–$250k24 Jul 2026filed 22 Sep 2026
Donald J. Trump Executive branch: Office of Government EthicsWhite House Officebought$1k–$15k15 Jun 2026filed 22 Aug 2026
Donald J. Trump Executive branch: Office of Government EthicsWhite House Officesold$15k–$50k15 May 2026filed 1 Jul 2026
Chris Jacobs House: U.S. House ClerkNY27bought$1k–$15k12 Dec 2022filed 20 Jan 2023

Insiders

Buy orders, 12 months0
Sale orders, 12 months18
Buyers · sellers0 · 6
WhoDidSharesTraded
Krish S. KrishnanPresident and CEOsold520at $354.544 Sep 2026filed 4 Sep 2026
Krish S. KrishnanPresident and CEOsold2,029at $355.574 Sep 2026filed 4 Sep 2026
Krish S. KrishnanPresident and CEOsold3,297at $356.374 Sep 2026filed 4 Sep 2026
Krish S. KrishnanPresident and CEOsold3,981at $357.574 Sep 2026filed 4 Sep 2026
Krish S. KrishnanPresident and CEOsold3,143at $358.424 Sep 2026filed 4 Sep 2026
Krish S. KrishnanPresident and CEOsold3,357at $359.394 Sep 2026filed 4 Sep 2026
Krish S. KrishnanPresident and CEOsold2,266at $360.464 Sep 2026filed 4 Sep 2026
Krish S. KrishnanPresident and CEOsold1,214at $361.614 Sep 2026filed 4 Sep 2026
Krish S. KrishnanPresident and CEOsold2,010at $362.654 Sep 2026filed 4 Sep 2026
Krish S. KrishnanPresident and CEOsold573at $363.344 Sep 2026filed 4 Sep 2026
Krish S. KrishnanPresident and CEOsold1,358at $364.484 Sep 2026filed 4 Sep 2026
Krish S. KrishnanPresident and CEOsold847at $365.424 Sep 2026filed 4 Sep 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders391+49 on the quarter
New · exited91 · 41
Reported value$10.7B

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

ManagerSharesChange
FMR LLCadded · filed 13 Aug 20264,418,197$1.6B+44,210+1.0%
BlackRock, Inc.added · filed 7 Aug 20264,181,432$1.6B+240,976+6.1%
Avoro Capital Advisors LLCunchanged · filed 14 Aug 20262,888,888$1.1B00.0%
VANGUARD PORTFOLIO MANAGEMENT LLCadded · filed 13 Aug 20261,574,905$585.3M+118,178+8.1%
STATE STREET CORPadded · filed 7 Aug 20261,351,158$502.2M+36,724+2.8%
VANGUARD CAPITAL MANAGEMENT LLCadded · filed 13 Aug 20261,240,567$461.1M+75,243+6.5%
Soleus Capital Management, L.P.reduced · filed 11 Aug 2026939,254$349.1M-213,833−18.5%
Capital World Investorsreduced · filed 12 Aug 2026777,843$289.1M-46,877−5.7%
GEODE CAPITAL MANAGEMENT, LLCadded · filed 12 Aug 2026698,993$259.8M+55,018+8.5%
Hood River Capital Management LLCadded · filed 14 Aug 2026663,375$246.6M+43,789+7.1%
31 Mar 2023 – 30 Jun 2026
136259381Mar 23Dec 23Dec 24Sep 25Jun 26

Everyone who traded it

Catherine Mazzacco Company insiderDirector · last 14 Sep 20260 · 0
Christopher Mason Company insiderDirector · last 14 Sep 20260 · 0
Daniel Janney Company insiderDirector · last 14 Sep 20261 · 12
Dino A. Rossi Company insiderDirector · last 14 Sep 20260 · 3
Everett Rand Sutherland Company insiderDirector · last 14 Sep 20260 · 0
Julian S. Gangolli Company insiderDirector · last 14 Sep 20260 · 1
Krish S. Krishnan Company insiderPresident and CEO · last 4 Sep 20263 · 35
Suma Krishnan Company insiderPresident, R&D · last 4 Sep 20264 · 38
Donald J. Trump Executive branchWhite House Office · last 24 Jul 20261 · 2
John Charles Thomas Company insiderEVP, General Counsel · last 25 Jun 20260 · 2
Kathryn Romano Company insiderChief Accounting Officer · last 2 Mar 20260 · 9
Andrew C. Orth Company insiderChief Commercial Officer · last 9 Jun 20230 · 1

Same industry

MRNA ModernaLeading+147%
ENTX Entera BioLeading+37%
XNCR XencorLeading+30%

Distance from each stock’s own 150-day average.

Government contracts

No federal award is tied to it.

From its SEC filings

Operating profit marginFY 2025 · to 31 Dec 202541.5%
Free cash flow marginFY 2025 · to 31 Dec 202548.5%
Return on capital employedFY 2025 · to 31 Dec 202513.1%
Cash conversionFY 2025 · to 31 Dec 202598.1%
Research spendFY 2025 · to 31 Dec 202514.9%
Share count trendFY 2025 · to 11 Feb 20260.1%
Cash and equivalentsFY 2025 · to 31 Dec 2025$496.3M
Free cash flowFY 2025 · to 31 Dec 2025$188.9M

Analyst forecasts

No analyst forecasts yet.