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The company

Praxis Precision Medicines, Inc.

PRAX · Nasdaq

Health CareBiotechnologyNot moving yet

PRAX stood above a rising 150-day average in 43 of the last 52 weekly readings, and has been out of that trend for the last 5 weeks. It is 23.8% below that average now. Biotechnology: 15% of its 561 stocks in an uptrend (−17 points in four weeks); Health Care: 25% (−11 points in four weeks).

SEC filings

Statistics

Rotation: Not moving yet
Weeks in an uptrend: out for 5
Industry in uptrend: 15% -17 in 4 wk
Insider buys, 12 months: $0
Insider sales, 12 months: $14.7M
Officials’ trades on record: 2
Institutions holding: 295 (+17)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 43 of 52 weeks.

17 Apr – 16 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

2 disclosed lines: House 2, Senate 0, executive 0; 1 people.

Who	Did	Amount	Traded
Gilbert Ray Cisneros, Jr. House: U.S. House ClerkCA31	bought	$1k–$15k	29 Sep 2026filed 12 Oct 2026
Gilbert Ray Cisneros, Jr. House: U.S. House ClerkCA31	bought	$1k–$15k	30 Jul 2026filed 4 Sep 2026

Insiders

Buy orders, 12 months0

Sale orders, 12 months3

Buyers · sellers0 · 3

Who	Did	Shares	Traded
Jill DesimoneDirector	sold	10at $301.44	24 Jun 2026filed 26 Jun 2026
Jill DesimoneDirector	sold	120at $303.13	24 Jun 2026filed 26 Jun 2026
Jill DesimoneDirector	sold	320at $305.31	24 Jun 2026filed 26 Jun 2026
Jill DesimoneDirector	sold	683at $306.77	24 Jun 2026filed 26 Jun 2026
Jill DesimoneDirector	sold	1,240at $308.24	24 Jun 2026filed 26 Jun 2026
Jill DesimoneDirector	sold	999at $309.38	24 Jun 2026filed 26 Jun 2026
Jill DesimoneDirector	sold	1,750at $310.89	24 Jun 2026filed 26 Jun 2026
Jill DesimoneDirector	sold	2,854at $311.91	24 Jun 2026filed 26 Jun 2026
Jill DesimoneDirector	sold	1,004at $312.83	24 Jun 2026filed 26 Jun 2026
Jill DesimoneDirector	sold	504at $313.66	24 Jun 2026filed 26 Jun 2026
Jill DesimoneDirector	sold	1,279at $314.90	24 Jun 2026filed 26 Jun 2026
Jill DesimoneDirector	sold	837at $315.71	24 Jun 2026filed 26 Jun 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders295+17 on the quarter

New · exited58 · 40

Reported value$11.0B

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
Jupiter Topco LLCnew · filed 14 Aug 2026	3,421,374$1.1B	+3,421,374
FMR LLCadded · filed 13 Aug 2026	2,316,907$775.7M	+155,964+7.2%
BlackRock, Inc.reduced · filed 7 Aug 2026	2,292,585$767.5M	-32,344−1.4%
PERCEPTIVE ADVISORS LLCunchanged · filed 14 Aug 2026	2,035,986$681.6M	00.0%
BAKER BROS. ADVISORS LPunchanged · filed 14 Aug 2026	1,753,198$587.0M	00.0%
Orbis Allan Gray Ltdreduced · filed 14 Aug 2026	1,529,788$512.2M	-942,692−38.1%
VANGUARD PORTFOLIO MANAGEMENT LLCadded · filed 13 Aug 2026	1,335,185$447.0M	+578,437+76.4%
VANGUARD CAPITAL MANAGEMENT LLCadded · filed 13 Aug 2026	1,235,299$413.6M	+13,355+1.1%
STATE STREET CORPadded · filed 7 Aug 2026	1,026,443$343.7M	+142,205+16.1%
ADAGE CAPITAL PARTNERS GP, L.L.C.added · filed 14 Aug 2026	1,015,480$340.0M	+199,741+24.5%