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The company

Prelude Therapeutics Incorporated

PRLD · Nasdaq

Health CareBiotechnologyNot moving yet

PRLD stood above a rising 150-day average in 48 of the last 52 weekly readings, and has been out of that trend for the last 4 weeks. It is 26.6% below that average now. Biotechnology: 15% of its 561 stocks in an uptrend (−17 points in four weeks); Health Care: 25% (−11 points in four weeks).

SEC filings

Statistics

Rotation: Not moving yet
Weeks in an uptrend: out for 4
Industry in uptrend: 15% -17 in 4 wk
Insider buys, 12 months: $50.0M
Insider sales, 12 months: $0
Officials’ trades on record: 0
Institutions holding: 74 (+22)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 48 of 52 weeks.

17 Apr – 16 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months3

Sale orders, 12 months0

Buyers · sellers3 · 0

Who	Did	Shares	Traded
Orbimed Advisors LlcDirector, 10% owner	bought	1,689,189at $4.44	21 Apr 2026filed 23 Apr 2026
Orbimed Advisors LlcDirector, 10% owner	bought	1,126,126at $4.44	21 Apr 2026filed 23 Apr 2026
David P. BonitaDirector, 10% owner	bought	1,689,189at $4.44	21 Apr 2026filed 23 Apr 2026
David P. BonitaDirector, 10% owner	bought	1,126,126at $4.44	21 Apr 2026filed 23 Apr 2026
Baker Bros. Advisors LpDirector, 10% owner	bought	114,601at $4.44	21 Apr 2026filed 22 Apr 2026
Baker Bros. Advisors LpDirector, 10% owner	bought	2,137,651at $4.44	21 Apr 2026filed 22 Apr 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders74+22 on the quarter

New · exited35 · 13

Reported value$261.3M

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
ORBIMED ADVISORS LLCadded · filed 14 Aug 2026	13,724,571$73.2M	+2,815,315+25.8%
BAKER BROS. ADVISORS LPunchanged · filed 14 Aug 2026	10,123,824$54.0M	00.0%
RA CAPITAL MANAGEMENT, L.P.new · filed 14 Aug 2026	6,475,882$34.5M	+6,475,882
Soleus Capital Management, L.P.new · filed 11 Aug 2026	3,378,378$18.0M	+3,378,378
Kynam Capital Management, LPadded · filed 14 Aug 2026	2,415,087$12.9M	+822,536+51.6%
VANGUARD CAPITAL MANAGEMENT LLCadded · filed 13 Aug 2026	2,009,445$10.7M	+779,039+63.3%
BlackRock, Inc.added · filed 7 Aug 2026	1,797,501$9.6M	+1,475,615+458.4%
SPHERA FUNDS MANAGEMENT LTD.added · filed 14 Aug 2026	1,019,832$5.4M	+461,493+82.7%
TWO SIGMA INVESTMENTS, LPadded · filed 14 Aug 2026	993,369$5.3M	+69,743+7.6%
ADAR1 Capital Management, LLCadded · filed 14 Aug 2026	900,900$4.8M	+748,075+489.5%