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The company

Septerna, Inc.

SEPN · Nasdaq

Health CareBiotechnologyLeading

SEPN stood above a rising 150-day average in 49 of the last 52 weekly readings, including each of the last 23 weeks. It is 23.2% above that average now. Biotechnology: 18% of its 561 stocks in an uptrend (−12 points in four weeks); Health Care: 28% (−6 points in four weeks).

SEC filings

Statistics

Rotation: Leading
Weeks in an uptrend: 23 in a row
Industry in uptrend: 18% -12 in 4 wk
Insider buys, 12 months: $0
Insider sales, 12 months: $152.2M
Officials’ trades on record: 0
Institutions holding: 149 (+31)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 49 of 52 weeks.

22 Apr – 21 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has been slipping.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months0

Sale orders, 12 months19

Buyers · sellers0 · 7

Who	Did	Shares	Traded
Elizabeth BhattPresident and COO	sold	1,094at $36.87	15 Oct 2026filed 19 Oct 2026
Elizabeth BhattPresident and COO	sold	2,906at $37.61	15 Oct 2026filed 19 Oct 2026
Daniel D. LongSVP, Drug Discovery	sold	3,333at $37.83	1 Sep 2026filed 3 Sep 2026
Third Rock Ventures V, L.p.10% owner	sold	147,059at $50.27	12 Aug 2026filed 14 Aug 2026
Third Rock Ventures V, L.p.10% owner	sold	141at $51.08	12 Aug 2026filed 14 Aug 2026
Ra Capital Management, L.p.Director, 10% owner	sold	746,500at $42.50	12 Aug 2026filed 14 Aug 2026
Ra Capital Management, L.p.Director, 10% owner	sold	746,500at $42.50	12 Aug 2026filed 14 Aug 2026
Elizabeth BhattPresident and COO	sold	25,000at $44.00	11 Aug 2026filed 13 Aug 2026
Daniel D. LongSVP, Drug Discovery	sold	1,000at $33.98	3 Aug 2026filed 5 Aug 2026
Daniel D. LongSVP, Drug Discovery	sold	2,334at $34.68	3 Aug 2026filed 5 Aug 2026
Elizabeth BhattPresident and COO	sold	4,000at $33.99	15 Jul 2026filed 17 Jul 2026
Daniel D. LongSVP, Drug Discovery	sold	2,100at $34.10	1 Jul 2026filed 2 Jul 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders149+31 on the quarter

New · exited48 · 17

Reported value$1.6B

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
RA CAPITAL MANAGEMENT, L.P.unchanged · filed 14 Aug 2026	6,995,858$234.3M	00.0%
TRV GP V, LLCunchanged · filed 10 Aug 2026	6,215,591$208.2M	00.0%
Driehaus Capital Management LLCadded · filed 14 Aug 2026	4,433,058$148.5M	+37,486+0.9%
TRV GP VI, LLCunchanged · filed 10 Aug 2026	4,211,659$141.0M	00.0%
SAMSARA BIOCAPITAL, LLCunchanged · filed 14 Aug 2026	3,149,128$105.5M	00.0%
GOLDMAN SACHS GROUP INCadded · filed 14 Aug 2026	3,062,766$102.6M	+156,339+5.4%
BlackRock, Inc.added · filed 7 Aug 2026	1,932,088$64.7M	+109,914+6.0%
Siren, L.L.C.reduced · filed 13 Aug 2026	1,900,000$63.6M	-100,000−5.0%
Avoro Capital Advisors LLCunchanged · filed 14 Aug 2026	1,337,500$44.8M	00.0%
Jupiter Topco LLCnew · filed 14 Aug 2026	1,307,500$43.7M	+1,307,500