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The company

Sionna Therapeutics, Inc.

SION · Nasdaq

Health CareBiotechnologyNot moving yet

SION stood above a rising 150-day average in 39 of the last 52 weekly readings, and has been out of that trend for the last 10 weeks. It is 86.9% below that average now. Biotechnology: 15% of its 561 stocks in an uptrend (−17 points in four weeks); Health Care: 25% (−11 points in four weeks).

SEC filings

Statistics

Rotation: Not moving yet
Weeks in an uptrend: out for 10
Industry in uptrend: 15% -17 in 4 wk
Insider buys, 12 months: $0
Insider sales, 12 months: $305.5M
Officials’ trades on record: 0
Institutions holding: 145 (+28)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 39 of 52 weeks.

17 Apr – 16 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months0

Sale orders, 12 months59

Buyers · sellers0 · 11

Who	Did	Shares	Traded
Ra Capital Management, L.p.Director, 10% owner	sold	3,415,011at $6.32	17 Sep 2026filed 21 Sep 2026
Ra Capital Management, L.p.Director, 10% owner	sold	33,800at $7.46	17 Sep 2026filed 21 Sep 2026
Orbimed Advisors LlcDirector	sold	85,918at $44.86	7 Jul 2026filed 9 Jul 2026
Peter A. ThompsonDirector	sold	85,918at $44.86	7 Jul 2026filed 9 Jul 2026
Jennifer FitzpatrickChief Legal Officer	sold	10,250at $43.60	6 Jul 2026filed 7 Jul 2026
Orbimed Advisors LlcDirector	sold	115,844at $45.50	30 Jun 2026filed 2 Jul 2026
Peter A. ThompsonDirector	sold	115,844at $45.50	30 Jun 2026filed 2 Jul 2026
Orbimed Advisors LlcDirector	sold	101at $44.49	27 May 2026filed 29 May 2026
Peter A. ThompsonDirector	sold	101at $44.49	27 May 2026filed 29 May 2026
Orbimed Advisors LlcDirector	sold	184,639at $46.22	11 May 2026filed 11 May 2026
Peter A. ThompsonDirector	sold	184,639at $46.22	11 May 2026filed 11 May 2026
Orbimed Advisors LlcDirector	sold	59,767at $44.58	8 May 2026filed 11 May 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders145+28 on the quarter

New · exited37 · 9

Reported value$2.1B

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
RA CAPITAL MANAGEMENT, L.P.unchanged · filed 14 Aug 2026	9,905,045$435.7M	00.0%
TPG GP A, LLCunchanged · filed 14 Aug 2026	6,494,962$285.7M	00.0%
VIKING GLOBAL INVESTORS LPunchanged · filed 14 Aug 2026	3,195,181$140.6M	00.0%
Atlas Venture Life Science Advisors, LLCunchanged · filed 13 Aug 2026	2,995,602$131.8M	00.0%
ORBIMED ADVISORS LLCreduced · filed 14 Aug 2026	2,555,877$112.4M	-974,825−27.6%
ENAVATE SCIENCES GP, LLCunchanged · filed 14 Aug 2026	2,478,030$109.0M	00.0%
ADAGE CAPITAL PARTNERS GP, L.L.C.added · filed 14 Aug 2026	1,600,000$70.4M	+1,450,000+966.7%
JPMORGAN CHASE & COnew · filed 12 Aug 2026	1,490,508$64.1M	+1,490,508
BlackRock, Inc.added · filed 7 Aug 2026	1,474,769$64.9M	+178,902+13.8%
JENNISON ASSOCIATES LLCreduced · filed 3 Aug 2026	1,172,133$51.6M	-279,087−19.2%