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The company

Spruce Biosciences, Inc.

SPRB · Nasdaq

Health CareBiotechnologyNot moving yet

SPRB stood above a rising 150-day average in 15 of the last 50 weekly readings, and has been out of that trend for the last 35 weeks. It is 23.8% below that average now. Biotechnology: 16% of its 561 stocks in an uptrend (−15 points in four weeks); Health Care: 26% (−10 points in four weeks).

SEC filings

Statistics

Rotation: Not moving yet
Weeks in an uptrend: out for 35
Industry in uptrend: 16% -15 in 4 wk
Insider buys, 12 months: $0
Insider sales, 12 months: $0
Officials’ trades on record: 0
Institutions holding: 64 (+35)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 15 of 50 weeks.

20 Apr – 19 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months0

Sale orders, 12 months0

Buyers · sellers0 · 0

No open-market buy or sale by its insiders on record.

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders64+35 on the quarter

New · exited39 · 4

Reported value$108.5M

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
AIGH Capital Management LLCnew · filed 7 Aug 2026	250,000$13.5M	+250,000
ORBIMED ADVISORS LLCnew · filed 14 Aug 2026	200,000$10.8M	+200,000
BlackRock, Inc.added · filed 7 Aug 2026	187,836$10.1M	+170,898+1009.0%
MILLENNIUM MANAGEMENT LLCadded · filed 14 Aug 2026	160,981$8.7M	+49,093+43.9%
Ikarian Capital, LLCunchanged · filed 14 Aug 2026	121,356$6.6M	00.0%
VANGUARD CAPITAL MANAGEMENT LLCnew · filed 13 Aug 2026	119,331$6.4M	+119,331
Alyeska Investment Group, L.P.added · filed 14 Aug 2026	81,671$4.4M	+30,000+58.1%
GEODE CAPITAL MANAGEMENT, LLCadded · filed 12 Aug 2026	70,548$3.8M	+57,659+447.4%
ADAR1 Capital Management, LLCadded · filed 14 Aug 2026	67,717$3.7M	+9,117+15.6%
Cable Car Capital, LPnew · filed 14 Aug 2026	60,000$3.2M	+60,000