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The company

Stoke Therapeutics, Inc.

STOK · Nasdaq

Health CareBiotechnologyNot moving yetSynthetic Biology / TechBio

STOK stood above a rising 150-day average in 30 of the last 52 weekly readings, and has been out of that trend for the last 15 weeks. It is 21.4% below that average now. Biotechnology: 15% of its 561 stocks in an uptrend (−17 points in four weeks); Health Care: 25% (−11 points in four weeks).

SEC filings

Statistics

Rotation: Not moving yet
Weeks in an uptrend: out for 15
Industry in uptrend: 15% -17 in 4 wk
Insider buys, 12 months: $0
Insider sales, 12 months: $13.6M
Officials’ trades on record: 0
Institutions holding: 190 (+4)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 30 of 52 weeks.

17 Apr – 16 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months0

Sale orders, 12 months43

Buyers · sellers0 · 8

Who	Did	Shares	Traded
Jonathan AllanGENERAL COUNSEL & CORP SEC	sold	627at $26.33	2 Oct 2026filed 2 Oct 2026
Barry TichoCHIEF MEDICAL OFFICER	sold	1,051at $26.16	1 Oct 2026filed 2 Oct 2026
Barry TichoCHIEF MEDICAL OFFICER	sold	3,945at $30.51	1 Sep 2026filed 3 Sep 2026
Barry TichoCHIEF MEDICAL OFFICER	sold	1,600at $31.06	1 Sep 2026filed 3 Sep 2026
Edward M. Md KayeDirector	sold	11,930at $32.01	18 Aug 2026filed 18 Aug 2026
Edward M. Md KayeDirector	sold	637at $32.47	18 Aug 2026filed 18 Aug 2026
Barry TichoCHIEF MEDICAL OFFICER	sold	4,525at $32.01	18 Aug 2026filed 18 Aug 2026
Barry TichoCHIEF MEDICAL OFFICER	sold	242at $32.47	18 Aug 2026filed 18 Aug 2026
Jonathan AllanGENERAL COUNSEL & CORP SEC	sold	2,716at $32.01	18 Aug 2026filed 18 Aug 2026
Jonathan AllanGENERAL COUNSEL & CORP SEC	sold	145at $32.47	18 Aug 2026filed 18 Aug 2026
Barry TichoCHIEF MEDICAL OFFICER	sold	5,907at $28.95	3 Aug 2026filed 5 Aug 2026
Barry TichoCHIEF MEDICAL OFFICER	sold	1,269at $29.45	3 Aug 2026filed 5 Aug 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders190+4 on the quarter

New · exited33 · 28

Reported value$2.3B

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
BlackRock, Inc.added · filed 7 Aug 2026	5,877,357$192.3M	+491,643+9.1%
RTW INVESTMENTS, LPunchanged · filed 14 Aug 2026	5,623,525$184.0M	00.0%
FMR LLCreduced · filed 13 Aug 2026	5,313,100$173.8M	-70,566−1.3%
Lynx1 Capital Management LPreduced · filed 12 Aug 2026	4,038,404$132.1M	-725,269−15.2%
Redmile Group, LLCreduced · filed 14 Aug 2026	3,945,920$129.1M	-218,200−5.2%
WELLINGTON MANAGEMENT GROUP LLPadded · filed 14 Aug 2026	3,519,301$115.2M	+423,601+13.7%
MORGAN STANLEYadded · filed 13 Aug 2026	3,452,795$113.0M	+29,515+0.9%
BAKER BROS. ADVISORS LPunchanged · filed 14 Aug 2026	3,336,697$109.2M	00.0%
TORONTO DOMINION BANKunchanged · filed 14 Aug 2026	3,173,258$103.8M	00.0%
STATE STREET CORPadded · filed 7 Aug 2026	2,852,240$93.3M	+575,728+25.3%