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The company

Upstream Bio, Inc.

UPB · Nasdaq

Health CareBiotechnologyNot moving yet

UPB stood above a rising 150-day average in 16 of the last 52 weekly readings, and has been out of that trend for the last 36 weeks. It is 62.3% below that average now. Biotechnology: 15% of its 561 stocks in an uptrend (−17 points in four weeks); Health Care: 25% (−11 points in four weeks).

SEC filings

Statistics

Rotation: Not moving yet
Weeks in an uptrend: out for 36
Industry in uptrend: 15% -17 in 4 wk
Insider buys, 12 months: $0
Insider sales, 12 months: $210K
Officials’ trades on record: 0
Institutions holding: 144 (+8)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 16 of 52 weeks.

17 Apr – 16 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months0

Sale orders, 12 months15

Buyers · sellers0 · 5

Who	Did	Shares	Traded
Allison AmbroseGeneral Counsel	sold	485at $5.49	16 Sep 2026filed 17 Sep 2026
Michael GrayCFO and COO	sold	853at $5.49	16 Sep 2026filed 17 Sep 2026
Adam HoughtonChief Business Officer	sold	700at $5.49	16 Sep 2026filed 17 Sep 2026
Everett Rand SutherlandChief Executive Officer	sold	2,095at $5.49	16 Sep 2026filed 17 Sep 2026
Aaron DeykinChief Medical Officer	sold	895at $5.49	16 Sep 2026filed 17 Sep 2026
Allison AmbroseGeneral Counsel	sold	477at $6.10	16 Jun 2026filed 17 Jun 2026
Aaron DeykinChief Medical Officer	sold	895at $6.10	16 Jun 2026filed 17 Jun 2026
Adam HoughtonChief Business Officer	sold	700at $6.10	16 Jun 2026filed 17 Jun 2026
Everett Rand SutherlandChief Executive Officer	sold	2,095at $6.10	16 Jun 2026filed 17 Jun 2026
Michael GrayCFO and COO	sold	853at $6.10	16 Jun 2026filed 17 Jun 2026
Adam HoughtonChief Business Officer	sold	699at $9.29	16 Mar 2026filed 17 Mar 2026
Allison AmbroseGeneral Counsel	sold	475at $9.29	16 Mar 2026filed 17 Mar 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders144+8 on the quarter

New · exited37 · 28

Reported value$348.5M

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
FMR LLCadded · filed 13 Aug 2026	8,162,897$56.5M	+61,334+0.8%
ORBIMED ADVISORS LLCunchanged · filed 14 Aug 2026	5,693,589$39.4M	00.0%
NORGES BANKnew · filed 12 Aug 2026	3,768,619$26.1M	+3,768,619
BlackRock, Inc.added · filed 7 Aug 2026	3,753,358$26.0M	+382,669+11.4%
Decheng Capital LLCunchanged · filed 14 Aug 2026	2,724,868$18.9M	00.0%
ENAVATE SCIENCES GP, LLCunchanged · filed 14 Aug 2026	2,459,703$17.0M	00.0%
VANGUARD CAPITAL MANAGEMENT LLCadded · filed 13 Aug 2026	1,876,734$13.0M	+3,160+0.2%
MILLENNIUM MANAGEMENT LLCadded · filed 14 Aug 2026	1,143,775$7.9M	+206,452+22.0%
D. E. Shaw & Co., Inc.added · filed 14 Aug 2026	1,036,044$7.2M	+215,564+26.3%
JPMORGAN CHASE & COnew · filed 12 Aug 2026	1,012,044$7.0M	+1,012,044