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The company

Wave Life Sciences, Inc.

WVE · Nasdaq

Health CareBiotechnologyNot moving yetGLP-1Synthetic Biology / TechBio

WVE stood above a rising 150-day average in 16 of the last 52 weekly readings, and has been out of that trend for the last 30 weeks. It is 42.6% below that average now. Biotechnology: 18% of its 561 stocks in an uptrend (−14 points in four weeks); Health Care: 28% (−9 points in four weeks).

SEC filings

Statistics

Rotation: Not moving yet
Weeks in an uptrend: out for 30
Industry in uptrend: 18% -14 in 4 wk
Insider buys, 12 months: $137.2M
Insider sales, 12 months: $17.2M
Officials’ trades on record: 0
Institutions holding: 228 (+10)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 16 of 52 weeks.

21 Apr – 20 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months5

Sale orders, 12 months20

Buyers · sellers2 · 11

Who	Did	Shares	Traded
Adrian RawcliffeDirector	sold	12,700at $5.29	12 Aug 2026filed 13 Aug 2026
Aik Na TanDirector	sold	432at $6.01	11 Aug 2026filed 13 Aug 2026
Ken TakanashiDirector	sold	3,864at $6.01	11 Aug 2026filed 13 Aug 2026
Heidi L. WagnerDirector	sold	7,000at $6.01	11 Aug 2026filed 13 Aug 2026
Ra Capital Management, L.p.Director, 10% owner	bought	971,091at $6.50	30 Mar 2026filed 30 Mar 2026
Ra Capital Management, L.p.Director, 10% owner	bought	2,495,623at $6.43	27 Mar 2026filed 30 Mar 2026
Ra Capital Management, L.p.Director, 10% owner	bought	4,954,558at $6.06	26 Mar 2026filed 30 Mar 2026
Ra Capital Management, L.p.Director, 10% owner	bought	351,224at $6.38	26 Mar 2026filed 30 Mar 2026
Chris FrancisOfficer	sold	17,900at $15.09	26 Feb 2026filed 27 Feb 2026
Chris FrancisOfficer	sold	15,294at $15.00	26 Feb 2026filed 27 Feb 2026
Chandra VargeeseOfficer	sold	3,228at $13.45	9 Feb 2026filed 11 Feb 2026
Chris FrancisOfficer	sold	1,883at $13.45	9 Feb 2026filed 11 Feb 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders228+10 on the quarter

New · exited50 · 41

Reported value$1.1B

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
RA CAPITAL MANAGEMENT, L.P.unchanged · filed 14 Aug 2026	26,975,505$156.7M	00.0%
BlackRock, Inc.added · filed 7 Aug 2026	19,202,461$111.6M	+5,085,049+36.0%
GSK plcunchanged · filed 13 Aug 2026	18,245,691$106.0M	00.0%
MAVERICK CAPITAL LTDadded · filed 14 Aug 2026	10,278,115$59.7M	+116,716+1.1%
Driehaus Capital Management LLCadded · filed 14 Aug 2026	5,443,143$31.6M	+12,122+0.2%
PRIMECAP MANAGEMENT COadded · filed 14 Aug 2026	5,354,622$31.1M	+521,670+10.8%
683 Capital Management, LLCadded · filed 14 Aug 2026	4,950,000$28.8M	+50,000+1.0%
FMR LLCreduced · filed 13 Aug 2026	4,922,477$28.6M	-270,284−5.2%
STATE STREET CORPadded · filed 7 Aug 2026	4,839,317$28.1M	+1,165,284+31.7%
READYSTATE ASSET MANAGEMENT LPnew · filed 14 Aug 2026	4,727,139$27.5M	+4,727,139