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The company

Xilio Therapeutics, Inc.

XLO · Nasdaq

Health CareBiotechnologyJust dropped out

XLO stood above a rising 150-day average in 8 of the last 52 weekly readings, and has been out of that trend for the last 1 week. It is 4.0% below that average now. Biotechnology: 16% of its 561 stocks in an uptrend (−15 points in four weeks); Health Care: 26% (−10 points in four weeks).

SEC filings

Statistics

Rotation: Just dropped out
Weeks in an uptrend: out for 1
Industry in uptrend: 16% -15 in 4 wk
Insider buys, 12 months: $88K
Insider sales, 12 months: $11K
Officials’ trades on record: 0
Institutions holding: 25 (+3)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 8 of 52 weeks.

20 Apr – 19 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months1

Sale orders, 12 months2

Buyers · sellers1 · 2

Who	Did	Shares	Traded
James Samuel ShannonDirector	bought	5,000at $8.79	26 Mar 2026filed 30 Mar 2026
Gilead Sciences, Inc.10% owner	bought	3,739,000at $0.5349	13 Feb 2026filed 17 Feb 2026
Christopher James FrankenfieldChief Financial Officer	sold	7,030at $0.6432	2 Jan 2026filed 5 Jan 2026
Kevin M. BrennanSVP, FINANCE AND ACCOUNTING	sold	1,826at $0.6432	2 Jan 2026filed 5 Jan 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders25+3 on the quarter

New · exited10 · 7

Reported value$32.5M

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
Bain Capital Life Sciences Investors, LLCunchanged · filed 14 Aug 2026	664,021$6.4M	00.0%
GILEAD SCIENCES, INC.unchanged · filed 3 Aug 2026	650,389$6.2M	00.0%
ORBIMED ADVISORS LLCnew · filed 14 Aug 2026	592,300$5.7M	+592,300
Frazier Life Sciences Management, L.P.unchanged · filed 14 Aug 2026	422,505$4.0M	00.0%
Stonepine Capital Management, LLCadded · filed 14 Aug 2026	225,994$2.2M	+161,832+252.2%
VANGUARD CAPITAL MANAGEMENT LLCadded · filed 13 Aug 2026	178,517$1.7M	+54,857+44.4%
Sio Capital Management, LLCunchanged · filed 14 Aug 2026	152,464$1.5M	00.0%
ADAGE CAPITAL PARTNERS GP, L.L.C.new · filed 14 Aug 2026	111,541$1.1M	+111,541
Merck & Co., Inc.unchanged · filed 7 Aug 2026	105,982$1.0M	00.0%
RENAISSANCE TECHNOLOGIES LLCadded · filed 13 Aug 2026	64,153$615K	+14,587+29.4%