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The company

MBX Biosciences, Inc.

MBX · Nasdaq

Health CareBiotechnologyLeadingGLP-1

MBX stood above a rising 150-day average in 50 of the last 52 weekly readings, including each of the last 19 weeks. It is 9.6% above that average now. Biotechnology: 16% of its 561 stocks in an uptrend (−15 points in four weeks); Health Care: 26% (−10 points in four weeks).

SEC filings

Statistics

Rotation: Leading
Weeks in an uptrend: 19 in a row
Industry in uptrend: 16% -15 in 4 wk
Insider buys, 12 months: $1.1M
Insider sales, 12 months: $5.5M
Officials’ trades on record: 0
Institutions holding: 168 (+19)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 50 of 52 weeks.

20 Apr – 19 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months1

Sale orders, 12 months4

Buyers · sellers1 · 2

Who	Did	Shares	Traded
Salomon AzoulayChief Medical Officer	sold	370at $65.77	4 Aug 2026filed 5 Aug 2026
Salomon AzoulayChief Medical Officer	sold	55,000at $38.38	8 May 2026filed 11 May 2026
Salomon AzoulayChief Medical Officer	sold	15,003at $38.30	8 May 2026filed 11 May 2026
P. Kent HawrylukPresident & CEO	sold	607at $29.54	6 May 2026filed 8 May 2026
Salomon AzoulayChief Medical Officer	sold	231at $29.54	6 May 2026filed 8 May 2026
P. Kent HawrylukPresident & CEO	bought	18,500at $28.41	13 Mar 2026filed 16 Mar 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders168+19 on the quarter

New · exited40 · 21

Reported value$3.0B

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
Frazier Life Sciences Management, L.P.unchanged · filed 14 Aug 2026	6,652,013$367.2M	00.0%
FMR LLCadded · filed 13 Aug 2026	5,322,885$293.8M	+2,386,201+81.3%
WELLINGTON MANAGEMENT GROUP LLPadded · filed 14 Aug 2026	4,977,523$274.8M	+1,785,699+55.9%
NEA Management Company, LLCunchanged · filed 14 Aug 2026	3,614,486$199.5M	00.0%
ORBIMED ADVISORS LLCreduced · filed 14 Aug 2026	3,428,736$189.3M	-209,151−5.7%
BlackRock, Inc.added · filed 7 Aug 2026	3,323,672$183.5M	+382,266+13.0%
Paradigm Biocapital Advisors LPnew · filed 14 Aug 2026	2,508,015$138.4M	+2,508,015
NVP ASSOCIATES, LLCunchanged · filed 7 Aug 2026	2,136,335$117.9M	00.0%
Deep Track Capital, LPreduced · filed 14 Aug 2026	1,732,569$95.6M	-1,025,000−37.2%
Polar Capital Holdings Plcreduced · filed 14 Aug 2026	1,608,514$88.8M	-13,672−0.8%