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The company

Xenon Pharmaceuticals Inc. - Common Shares

XENE · Nasdaq

Health CareBiotechnologyNot moving yet

XENE stood above a rising 150-day average in 46 of the last 52 weekly readings, and has been out of that trend for the last 6 weeks. It is 34.5% below that average now. Biotechnology: 18% of its 561 stocks in an uptrend (−14 points in four weeks); Health Care: 28% (−9 points in four weeks).

SEC filings

Statistics

Rotation: Not moving yet
Weeks in an uptrend: out for 6
Industry in uptrend: 18% -14 in 4 wk
Insider buys, 12 months: $1.7M
Insider sales, 12 months: $42.8M
Officials’ trades on record: 0
Institutions holding: 299 (+27)

In the rotation

Each square a week: lit when it closed above a rising 150-day average. 46 of 52 weeks.

21 Apr – 20 Oct

Biotechnology: Few of its stocks are in an uptrend and the share has fallen sharply over four weeks. Health Care: A minority of its stocks are in an uptrend and the share has fallen sharply over four weeks.

Money in and out

1 Nov 2024 – 1 Oct 2026

Open-market buys above the line and sales below, in dollars.

Congress and officials

No member of Congress or official has disclosed a trade in it.

Insiders

Buy orders, 12 months2

Sale orders, 12 months15

Buyers · sellers2 · 6

Who	Did	Shares	Traded
Ian MortimerPRESIDENT & CEO	bought	30,000at $37.38	30 Sep 2026filed 1 Oct 2026
Thomas Patrick KellyChief Financial Officer	bought	15,000at $37.32	30 Sep 2026filed 1 Oct 2026
Christopher John KenneyChief Medical Officer	sold	6,368at $60.17	28 Aug 2026filed 31 Aug 2026
Christopher John KenneyChief Medical Officer	sold	700at $60.98	28 Aug 2026filed 31 Aug 2026
Steven GannonDirector	sold	10,000at $64.06	11 Aug 2026filed 13 Aug 2026
Gillian CannonDirector	sold	1,190at $53.14	5 Jun 2026filed 8 Jun 2026
Gary PatouDirector	sold	1,322at $53.14	5 Jun 2026filed 8 Jun 2026
Ian MortimerPRESIDENT & CEO	sold	7,308at $55.23	13 Mar 2026filed 13 Mar 2026
Andrea DifabioChief Legal Officer	sold	1,342at $55.23	13 Mar 2026filed 13 Mar 2026
Christopher John KenneyChief Medical Officer	sold	1,410at $55.23	13 Mar 2026filed 13 Mar 2026
Ian MortimerPRESIDENT & CEO	sold	11,269at $60.11	10 Mar 2026filed 11 Mar 2026
Andrea DifabioChief Legal Officer	sold	2,607at $60.11	10 Mar 2026filed 11 Mar 2026

Lines filed since 2 January 2026, newest first; every insider’s older lines are on their own page.

Institutions

Holders299+27 on the quarter

New · exited50 · 24

Reported value$5.8B

Quarter to 30 Jun 2026, against 31 Mar 2026; newest filing 31 Aug 2026.

Manager	Shares	Change
FMR LLCreduced · filed 13 Aug 2026	9,647,998$582.4M	-1,170,493−10.8%
BlackRock, Inc.added · filed 7 Aug 2026	7,522,482$454.1M	+1,882,364+33.4%
Avoro Capital Advisors LLCunchanged · filed 14 Aug 2026	5,777,777$348.7M	00.0%
Polar Capital Holdings Plcadded · filed 14 Aug 2026	4,570,556$275.9M	+165,244+3.8%
Driehaus Capital Management LLCreduced · filed 14 Aug 2026	4,418,557$266.7M	-73,096−1.6%
Jupiter Topco LLCnew · filed 14 Aug 2026	4,186,519$252.7M	+4,186,519
JPMORGAN CHASE & COnew · filed 12 Aug 2026	2,617,360$157.4M	+2,617,360
Capital International Investorsreduced · filed 12 Aug 2026	2,361,639$142.5M	-313,088−11.7%
STATE STREET CORPadded · filed 7 Aug 2026	1,969,629$118.9M	+249,096+14.5%
TWO SIGMA INVESTMENTS, LPadded · filed 14 Aug 2026	1,642,848$99.2M	+1,036,763+171.1%